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doi: 10.1038/nrn3071 6 DruckerDJ
Current Applications Differentiation into Insulin-Producing Cells Further applications for GLP1-RA, primarily Ex-4, on hMSC include the differentiation into insulin-producing cells (IPC), a process of significant interest for regenerative approaches in gastroenterology
Hussaini SH, Pereira SP, Murphy GM, Dowling RH (1995) Deoxycholic acid influences cholesterol solubilization and microcrystal nucleation time in gallbladder bile
Screen-based detection of intracellular cAMP Islets were plated in clear-bottom 96-well plates with KRB containing 2.8 mmol/l glucose and stimulated for 20 min at 37C with KRB (20 mmol/l glucose) plus IBMX (500 mol/l), either alone or combined with forskolin (10 mol/l), GLP-1 (1 nmol/l) or triagonist (1 nmol/l)
This co-secretion reflects coordinated regulation of nutrient intake and glucose handling
